Research Centre for Magnetic Resonance in Medicine

Bendahan David

Contract number

075-15-2021-592

Time span of the project

2021-2023

Laboratory's website

As of 01.11.2022

Number of staff members

scientific publications

Objects of intellectual property

In recent years, the scientific research in the field of MRI (magnetic resonance imaging, one of the most important non-invasive medical imaging methods) has been focused on the development of quantitative methods aimed the search for biomarkers for the early diagnostics and the assessment of the activity of diseases as well as of the efficiency of therapeutic strategies. In spite of the interest and promising prospects, these quantitative methods are not widely implemented in daily clinical practice, perhaps, due to the limitations of the internation between physicists and medical professionals who work on problems of magnetic resonance.

Name of the project: Advanced quantitative technologies in magnetic resonance imaging for the detection of the stages of inflammation and fibrosis as markers of diseases.

To achieve the goals of the project, the following tasks have been set for the team:

To develop new radio-frequency coils (RF coils) and substrates based on materials with high dielectric permeability and «artificial» materials with special electromagnetic properties for the improvement of the signal-to-noise ratio, the resolution of images, the homogeneity of the magnetic field in the area of interest, as well as the RF safety;
To develop special quantitative MRI methods and protocols for the early detection and control of inflammation and fibrosis in specific organs;
To develop post-processing methods on the basis of deep learning for the collection of quantitative metrics magnetic resonance images;
To research specific biomarkers for the assessment of the activity of diseases and the determination of the efficiency of therapeutic strategies.

Scientific results:

A method for measuring the volume of cartilage tissue of the wrist joint from MRI data with the use of convolutional neural network.
A methodology for multimodal Т2*-mapping of the liver for application in the diagnostics of hepatic iron overload.
A radio-frequency substrate for improving fetal MRI in a 3 T field.
A radio-frequency substrates based on «artificial» and dielectric materials for decreasing the number of artifacts related to the inhomogeneity of radio-frequency field in the area of the heart and the abdominal cavity.
A radio-frequency coils based on metamaterials to improve the signal/noise ratio of cartilage MR images as well as to increase the radio-frequency safety of the procedure.
Pulse sequence optimized via improved radio-frequency pulses that will be used with new radio-frequency devices, which will allow to better visualize the structure of the heart, the liver, and the cartilage.
The optimal set of the parameters of a pulse sequence of pulses (3D VIBE) for scanning patients with wrist joint pain and confirmed rheumatoid arthritis or osteoarthritis.
A multi-institutional data set for the testing and training of a 3D convolutional neural network for segmenting cartilage in wrists.
Labeling data for the training and testing of a special 3D convolutional neural network for wrist cartilage segmentation.
Phantoms with electromagnetic and relaxation properties that are close to the properties of living tissues.
A comparative analysis of methodologies for producing distributions of relaxation times of Т1, Т2 and Т2* in abdominal cavity organs and the influence of inhomogeneities of variable magnetic field on their precision.

Education and career development:

We conducted three scientific schools and conferences: «Magnetic Resonance in Medicine: the trends» (9 December 2021), «School of Magnetic Resonance Imaging» (27 June-2 July 2022), «Magnetic Resonance in Medicine: the trends» (10 November 2022).

Collaborations:

Center for Magnetic Resonance in Biology and Medicine (Frabce): joint research, collaborative scientific events, student exchanges.
V. A Almazov National Medical Research Center of the Ministry of Science and Higher Education of Russia: joint research, collaborative scientific events.

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vorobyev, v., shchelokova, a., efimtcev, a., baena, j. d., abdeddaim, r., belov, p., … glybovski, s.

Improving homogeneity in abdominal imaging at 3 T with light, flexible, and compact metasurface. Magnetic Resonance in Medicine. 2021, Ноябрь (87).

brui, e. a., rapacchi, s., bendahan, d., & andreychenko, a. e.

Comparative analysis of SINC-shaped and SLR pulses performance for contiguous multi-slice fast spin-echo imaging using metamaterial-based MRI. Magnetic Resonance Materials in Physics, Biology and Medicine. 2021, Декабрь (34).

brui e., mikhailovskaya a., solomakha g., efimtcev a., andreychenko a., shchelokova a.

Volumetric wireless coil for wrist MRI at 1.5 T as a practical alternative to Tx/Rx extremity coil: a comparative study. Journal of Magnetic Resonance. 2022, Июнь (339)

nasonov a., tikhonov p., shchelokova a., brui e.

Assessing Safety and Transceive Performance of a Body Coil Combined with a Volumetric Wireless Coil for Wrist MRI at 3 T. Applied Magnetic Resonance. 2022, Октябрь (53).

Hosting organization	Field of studies	City	Invited researcher	Time span of the project
Laboratory of Medical Bioresorption and Bioresistivity A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of the Russian Federation - (MSUMD)	Health sciences	Moscow	Shin Kwang Seon Korea	2022-2024
Arctic Biomonitoring Laboratory Northern (Arctic) Federal University named after M.V. Lomonosov - (NArFU)	Health sciences	Arkhangelsk	Thomassen Yngvar Norway	2017-2021