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Contract number
075-15-2022-1133
Time span of the project
2022-2024

As of 01.12.2023

29
Number of staff members
9
scientific publications
2
Objects of intellectual property
General information

Name of the project:

The development of substitutes for the foreign imported technology of the production of bioresorbable fixation systems made of magnesium alloys for osteosynthesis and   reconstructive treatment in medicine and veterinary medicine.

Research directions: Medical sciences and health studies

Goals and objectives

Goals of project:

To research the biocompatibility and bioresorption properties of alloys based on magnesium for the development of a technology for the manufacturing of systems for the fixation of hard tissues and subsequent osteogenesis and reconstructive interventions in various domains of medicine.

Project objective:

  1. To create new biomaterials possessing controllable resorption rate and specified    bioresistivity properties in biological media on the example of biocompatible alloys based on magnesium, zinc and iron as well as smart polymer medical materials.
  2. To develop industrial technologies for the production of medical products such as screws, pins etc. for the fixation of osteosynthesis of hard tissues in maxillofacial surgery, adult and  pediatric traumatology, neurosurgery (traumatic brain injury surgery and spinal trauma) as well as in veterinary medicine, including additive technologies for the manufacturing of biomimetic structures and structures produced by applying new approaches in 3D/4D printing for the manufacturing of  customized structural solutions.
  3. To conduct the preclinical and clinical testing of the most promising solutions for bioresorbable systems for the fixation and osteosynthesis of hard tissues to subsequently attain medical product registration certificate.
  4. To provide methodological and educational support to the practical use of the medical products developed with the participation of the Laboratory. 
The practical value of the study

Scientific results:

FSBEI HE "Russian University of Medicine" of the Ministry of Health of Russia, together with NUST MISIS, for the first time in Russia, developed, patented and put into production bioresorbable (biodegradable) fixation systems made of magnesium alloys of a unique composition and design for maxillofacial surgery, traumatology: screws, pins, plates, membranes.

Implementation of research results:

Russian bioresorbable fixation systems made of magnesium alloys for osteosynthesis and reconstructive treatment in medicine and veterinary medicine, according to the results of preclinical and clinical trials, are superior to foreign analogues. For the first time in Russia, the Russian University of Medicine proactively conducted clinical trials of products on patients, which confirmed the expected clinical effect

Organizational and infrastructural changes:

A world-class laboratory has been created

Education and personnel occupational retraining:

An educational course was conducted under the program: “Modern biodegradable materials in the maxillofacial area: development, research, application.”

Defended a PhD thesis on the topic: “Structure, mechanical and corrosion properties of bioresorbable magnesium alloys for medical purposes”

Cooperation:

Osteo-CyBer LLC, Gorky Medical Institute

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Rogachev, V.E. Bazhenov, A.A. Komissarov, A.V. Li, N.E. Munzaferova, S.V. Plegunova, and D.V. Ten
Microstructure, Mechanical, and Corrosion Properties of Mg-Zn-Ga Alloy after Hot Rolling, Rogachev, https://link.springer.com/article/10.1007/s11665-024-09361-2, 2024
Viacheslav E. Bazhenov, Alexander A. Komissarov a,d, Denis V. Ten, Anna V. Li a, Sofia V. Plegunova, Nikolay A. Redko, Alexey Yu. Drobyshev,
High strength and ductility in a new Mg–Zn–Ga biocompatible alloy by drawing and rotary forging https://doi.org/10.1016/j.rinma.2023.100524, 2024
Shin Kwan Son, Komissarov A.A., Bazhenov V.E.
Effects of temperature on critical resolved shear stresses of slip and twining in Mg single crystal via experimental and crystal plasticity modeling Journal of Magnesium and Alloys, 2023
lloys, Bazheno V.E., Drobyshev A.Yu., Lee A.V., Shin Kwang Son
Effect of Hot Rolling on Structure and Mechanical Properties of Mg–Y–Zn–Mn Metals, 2023
Sadykova Yu.A.
Artificial intelligence analysis of the sterilization effects on the mechanical properties of human cranial bones, International Journal of Minerals, Metallurgy and Materials, 2023
Other laboratories and scientists
Hosting organization
Field of studies
City
Invited researcher
Time span of the project
Research Centre for Magnetic Resonance in Medicine

ITMO University - (ITMO)

Health sciences

St. Petersburg

Bendahan David

France

2021-2023

Arctic Biomonitoring Laboratory

Northern (Arctic) Federal University named after M.V. Lomonosov - (NArFU)

Health sciences

Arkhangelsk

Thomassen Yngvar

Norway

2017-2021