Centre for Integrative Structural Biology (10)

Planned project results:

1. The Centre for Integrative Structural Biology will be established as a basis for the subsequent establishment of a consortium of academic organizations to carry out integrated structural biology research.
2. Industrially important enzymes with new or improved properties will be designed based on information about the three-dimensional structure of their active centers and strains will be created for biotechnological synthesis of important substances such as essential amino acids, hormones and enzymes.
3. Molecular mechanisms of interaction of inhibitors with their intracellular targets will be established and new targets will be sought for the development of highly selective antimicrobial agents for pharmacology and medicine.
4. Artificially engineered peptides that specifically inhibit key protein-protein interactions in macromolecular complexes will be developed.
5. Structural studies of damage and repair systems of bacterial translation systems will be carried out to create the basis for the development of antibacterial drugs with a fundamentally different mechanism of action and specificity compared to classical antibiotics.

The results will be used for the development and production of domestic modern drugs and enzymes that are necessary for the biotechnological industry.