Laboratory of Advanced Materials, Green Methods and Biotechnology

1. The Laboratory will develop prescribed conditions for the implementation of efficient methods of disposal of technological waste with the use of green methods, bio- and chemical transformations as well as combinations of those.
2. We will develop efficient green synthetic protocols for the production of promising ligands, fluorophores and pharmaceutical candidates of azaheterocyclic series as well as organic materials.
3. We will develop efficient methodologies for the creation of efficient next-generation medications as well as organic materials, for the theranostics of tumor conditions.
4. Our researchers will develop efficient methodologies for the creation of new   pharmaceuticals demonstrating antiviral activity.
5. We will produce biologically active substances, including astaxanthin, catechins, betulin as well as lysine, plant-based meat with extracts of algae and fungi, the sustainable thermally stable sweet protein mabinlins with improved taste as well as a protein feed concentrate for animal farming employing new “green” chemical and biological technologies. 
6. The Laboratory will determine the laws of the impact of the produced biologically active substances, lysine, plant-based meat with extracts of algae and fungi, the sweet protein – mabinlin as well as complex protein feed concentrates on the biochemical,, immunological indicators of blood and on morphological changes in tissues of organs. The research will be conducted using laboratory animal models in the context of the prevention and treatment of illnesses related to the development of metabolic syndrome, such as type 2 diabetes, obesity, cardiovascular conditions.

We are expecting to achieve the following results:

1. Efficient methods of the synthesis of (green and PASE-) of derivatives azaheterocyclic series (azines, azoloazines, including perhalogenated and boron-enriched), as a basis for the creation of promising ligands, fluorophores and pharmaceutical candidates.
2. Prospective candidates as CK2 kinase and deubiquitinase inhibitors as well as antitumor agents selected using “in-silico” screening methods.
3. Methods of the synthesis of new Au(I) and Au(III) complexes containing various substituents on the periphery of the ligand. An in-depth research of their structure, reaction capability in key reactions as well as biological action.
4. Methods of the synthesis of new azaheterocyclic ligands for the supramolecular extraction of lanthanide cations from water and organic solutions and the structures of the produced complexes.
5. Methods of the synthesis of new promising lanthanide complexes (Ln = Gd, Tb, Eu) based on azine ligands with additionally introduced fragments for the chelation of cations of the lanthanides, binding to biomolecules as well as fluorophore fragments.
6. Results of the research of the processes of the interaction of protein molecules with the synthesized azaheterocycles.
7. Results of the research of the antitumor activity of the selected promising candidates “in-vivo” and “ex-vivo”, results of the research of the «structure-activity» correlation as well as results of the selection of leading compounds.
8. Examples of new catalytic materials for the catalysis of key organic reactions as well as for the photocatalytic degradation of key organic pollutants.
9. Technologies for the efficient production of biologically active compounds such as astaxanthin, catechins, betulin as well as lysine, plant-based meat with the use of the extraction of plant raw materials based on bean protein and rice protein with the inclusion of algae extracts (Arthrospira maxima) and fungi (Lentinula edodes), the sustainable thermostable sweet protein, mabinlin, with improved taste that can be used as a sugar replacement in food products as well as protein in feed complexes produced from natural sources
10. Results of the research of the bioavailability and results of the precilinical testing involving laboratory models of type 2 diabetes, metabolic syndrome and cardiovascular diseases.