Laboratory of Advanced Materials, Green Methods and Biotechnology

Name of the project:

Green methods and biotransformation technologies for the creation of prospective materials that will be important for the theranostics of socially significant diseases, including SARS-CoV-2 and other viral infections and new (bio)pharmaceutical products.

Research directions: Chemistry and chemical technology

Goals of project:

The strategic goal of the project is to create highly-efficient technological solutions that can reduce the technogenic load on the environment, increase the life expectancy and the quality of life of the population by means of comprehensive use of rational and green organic synthesis, digital modeling, original biotechnologies approaches to the targeted design of prospective multipurpose materials for the theranostics of socially significant, predominantly oncological, as well as for new (bio)pharmaceutical products.

Project objective:

1. Developing a technology for the efficient production of biologically active compounds of plant-based meat with extracts of algae and fungi, sweet proteins as well as protein feed complexes made of waste from production and from natural sources, determining their bioavailability and conducting their preclinical testing on laboratory models of type 2 diabetes, metabolic syndrome, and cardiovascular diseases.
2. Developing efficient methods of photo-, sono- and mechanoactivation chemical reactions as well as constructing catalysts on solid carriers, catalysts based on natural minerals etc. Developing efficient green methods of technological waste treatment.
3. Developing efficient (green and/or PASE) methods of the synthesis of derivatives of azaheterocyclic series (azines, azoloazines, including perhalogenated and boron-enriched).
4. Thoroughly studying the applicability of the produced target azaheterocycles as ligands, fluorophores and pharmaceutical candidates.
5. Conducting a selection of prospective candidates as CK2 kinase and deubiquitinase inhibitors as well as antitumor agents using “in-silico” screening methods.
6. Studying the antitumor activity of prospective candidates “in-vivo” and “ex-vivo”, selecting leading compounds.
7. Developing efficient methods of the synthesis of azaheterocyclic ligands for the supramolecular extraction of cations of ligands from water/organic solutions.
8. Developing methods of the synthesis of lanthanide complexes (Ln = Gd, Tb, Eu) based on the produced azine ligands. Thoroughly investigating the structure of the produced complexes. Researching the impact of additionally introduced fragments on the efficiency of yjr chelation or sensibilization of lanthanide cations, the possibility of their binding to biomolecules and their photoluminescence properties.
9. Developing methods of the design of Au(I) and Au(III) complexes on the basis of the ligands synthesized in the process of the implementation of the project. Thoroughly researching the structure of the produced complexes, investigating the impact of the nature of the ligand on the reaction capability and (or) antitumor activity of the complex.