Laboratory of Macromolecular Design (10)

Name of the project:

Macromolecular design of polymeric materials for medical and technical purposes

Goals of project:

The goal of this project is to develop fundamentally new, environmentally friendly approaches for carrying out cationic polymerization of vinyl monomers, as well as in situ transformation of cationic polymerization into radical polymerization for the precision synthesis of functional polymers and more complex macromolecular structures for medical and technical purposes.

Project objective: 

1. Design and synthesis of new reversible chain transfer agents for chemo- and photoinitiated cationic polymerization of isobutylene using the reversible chain transfer mechanism.
2. Development of environmentally friendly methods for the production of mono-, di- and multifunctional polyisobutylenes with different end groups.
3. Creation of chemically resistant, gas-tight, self-healing protective coatings based on polyisobutylene for use in optoelectronics.
4. Synthesis of a number of unique block copolymers based on polyisobutylene by transformation of cationic polymerization into radical polymerization.
5. Assessment of the biocompatibility of block copolymers and their potential for use in medicine (coating of coronary stents, production of artificial heart valve, ophthalmic implants and vascular grafts).
6. Development of methods for the synthesis of amphiphilic block copolymers based on polyisobutylene to create smart systems for targeted drug delivery.
7. Entering technical testing of developed medical products (coronary stents, heart valve).