Laboratory for Systems Biology of Ageing

Scientific results:

1. Using ribosome profiling, we have described changes in protein biosynthesis in the liver and kidneys during aging. 
2. We have developed svist4get, software to visualize ribosome profiling data. 
3. A model has been developed that describes the complex dynamics of mortality  in the human population as a resultant between the diminishing child mortality related to selection and the increasing mortality due to aging which started before birth. 
4. We have determined signatures of transcription changes happening in organs of mice when life-prolonging interventions are made. 
5. We have determined changes occurring in organs of mice with depletion of the eEF2 translation factor (deceleration of translation). 
6. Using a yeast model, we have demonstrated that replacing a gene with a knockout cassette can lead to aberrative changes of the level of expression of adjacent genes in a mechanism related to the regulation. 
7. It has been demonstrated that the cyclic induction of the FOXM1 transcription factor in mice delays the development of natural and progeroid aging and prolongs life.

Education and career development:

• 3 Candidate of Sciences, 2 Doctor of Sciences dissertations have been prepared and defended.
• 4 lecture courses have been developed.
• 5 lecture courses and laboratory case studies have been created.
• Number of students who defended their graduation qualification works in the Laboratory over the course of its existence: 15.
• Number of postgraduate students who have worked in the Laboratory over the course of its existence: 8. 

Organizational and infrastructural transformations:

We have established work and service of general-use devices:

• MACS Quant flow-through cytofluorometer.
• CLARIOstar multi-modal tablet reader. 

• Brigham and Women’s Hospital, Harvard Medical School: joint projects, articles, internships of employees of the Laboratory.
• Skolkovo Institute of Science and Technology: joint scientific project.