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Contract number
075-15-2019-1885, 075-15-2022-1094
Time span of the project

As of 30.01.2020

Number of staff members
scientific publications
Objects of intellectual property
General information

Name of the project: Discovery of fundamental mechanisms of sleep for breakthrough technologies of neurorehabilitation medicine.

Goals and objectives
Project objective: Creation of a world-class «smart sleep» research laboratory for pioneering research of mechanisms underlying the phenomenon removal of toxins from brain tissue during sleep, creation of new scientific concepts in human and animal anatomy and physiology concerning structure and functions of cerebral lymphatic vessels as a drainage and cleaning system of the brain and characteristic properties of its nocturnal activity and development of breakthrough portable smart technologies to control regenerative properties of sleep for neurorehabilitation medicine

Oxana Semyachkina-Glushkovskaya, Ivan Fedosov, Alexander Shirokov, Elena Vodovozov, Anna Alekseev, Alexandr Khorovodov, Inna Blokhina, Andrey Terskov, Aysel Mamedova, Maria Klimova, Alexander Dubrovsky, Vasily Ageev, Ilana Agranovich, Valeria Vinnik, Anna Tsven, Sergey Sokolovski, Edik Rafailov, Thomas Penzel, Jürgen Kurths
Photomodulation of lymphatic delivery of liposomes to the brain bypassing the blood-brain barrier: new perspectives for glioma therapy. Journal of Nanophotonics. 2021, pp. 000010151520210212. https://doi.org/10.1515/nanoph-2021-0212. IF=8.499 (Q1)
Semyachkina-Glushkovskaya, O.; Mamedova, A.; Vinnik, V.; Klimova, M.; Saranceva, E.; Ageev, V.; Yu, T.; Zhu, D.; Penzel, T.; Kurths, J.
Brain Mechanisms of COVID-19-Sleep Disorders. Int. J. Mol. Sci. 2021, 22, 6917. https://doi.org/10.3390/ijms22136917. IF=4.556 (Q1). Has the status of a highly peer-reviewed article in MDPI in 2021.
Anastasiya Runnova, Maksim Zhuravlev, Rodion Ukolov, Inna Blokhina, Alexander Dubrovski, Nikita Lezhnev, Evgeniya Sitnikova, Elena Saranceva, Anton Kiselev, Anatoly Karavaev, Anton Selskii, Oxana Semyachkina-Glushkovskaya, Thomas Penzel & Jurgen Kurths.
Modified wavelet analysis of ECoG-pattern as promising tool for detection of the blood–brain barrier leakage. Scientific Reports 11, 18505 (2021). https://doi.org/10.1038/s41598-021-97427-9. IF= 4.379 (Q1)
Karavaev A.S., Ishbulatov Yu.M., Prokhorov M.D., Ponomarenko V.I., Kiselev A.R., Runnova A.E., Hramkov A.N., Semyachkina-Glushkovskaya O.V., Kurths J., Penzel T.
Simulating dynamics of circulation in the awake state and different stages of sleep using non-autonomous mathematical model with time delay. Front. Physiol., 13 January 2021 | https://doi.org/10.3389/fphys.2020.612787. IF= 4.134 (Q1)
Nadezhda Semenova, Konstantin Segreev, Andrei Slepnev, Anastasia Runnova, Maxim Zhuravlev, Inna Blokhina, Alexander Dubrovsky, Oxana Semyachkina-Glushkovskaya, Jurgen Kurths
Non-invasive analysis of blood-brain barrier permeability based on wavelet and machine learning approaches. Eur. Phys. J. Plus (2021) 136:736 https://doi.org/10.1140/epjp/s13360-021-01715-2. IF= 3.228 (Q1)
Oxana Semyachkina-Glushkovskaya, Dmitry Postnov, Anastasia Lavrova, Ivan Fedosov, Ekaterina Borisova, Vladimir Nikolenko, Thomas Penzel, Jurgen Kurths, Valery Tuchin
Biophotonic Strategies of Measurement and Stimulation of the Cranial and the Extracranial Lymphatic Drainage Function. IEEE Journal of Selected Topics in Quantum Electronics, vol. 27, no. 4, pp. 1-13, July-Aug. 2021, Art no. 7400313, doi: 10.1109/JSTQE.2020.3045834. IF = 4.917 (Q1)
A.N. Pavlov, A.I. Dubrovsky, A.A. Koronovskii Jr., O.N. Pavlova, O.V. Semyachkina-Glushkovskaya, and J. Kurths
Extended detrended fluctuation analysis of EEG signals during sleep and the opening of the blood-brain barrier. Chaos 30, 073138 (2020); https://doi.org/10.1063/5.0011823 (Q1)
Yurii M. Ishbulatov, Tatiana S. Bibicheva, Vladimir I. Gridnev, Mikhail D. Prokhorov, Marina V. Ogneva, Anton R. Kiselev and Anatoly S. Karavaev
Contribution of Cardiorespiratory Coupling to the Irregular Dynamics of the Human Cardiovascular System. Mathematics 2022, 10, 1088. https://doi.org/10.3390/math10071088. IF= 2.84 (Q1)
Semyachkina-Glushkovskaya O., Postnov D., Penzel T., Kurths J.
Sleep as a Novel Biomarker and a Promising Therapeutic Target for Cerebral Small Vessel Disease: A Review Focusing on Alzheimer’s Disease and the Blood-Brain Barrier. Int. J. Mol. Sci. 2020, 21, 6293; doi:10.3390/ijms21176293 (Q1)
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