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Laboratory for Genome Expression Regulation

Contract number
Time span of the project
Head of the laboratory

As of 01.11.2022

Number of staff members
scientific publications
General information

Name of the project: Study of molecular basics gene expression regulation in development of Drosophila

Goals and objectives

Research directions: At the Laboratory we research molecular basics of regulation of functioning of genes in the process of organism development

Project objective: At the Laboratory we research molecular basics of regulation of functioning of genes in the process of organism development

The practical value of the study

Scientific results:

  1. We have researched the molecular mechanisms of the control of the activity of enhancers, the functioning of insulators, the formation of the top chromatin structures. 
  2. Our researchers have studied the structure of the architectural factors of chromatin, transcription factors and RNA-binding proteins controlling the  expression of genes. 
  3. We have proposed new models of various stages of the process of gene expression. 
  4. We have determined the molecular foundations of a number of ontogenesis processes, the formation of cell polarity, the functioning  of the nervous system.

Education and career development:

  • One Doctor of Sciences dissertation, 7 Candidate of Sciences dissertations, 10 master’s, bachelor’s and specialist’s degree theses have been prepared and defended.
  • One scientific school has been conducted. 

Organizational and structural changes:

Employees of the Laboratory participate in the work of the Center for Genomics Research of the Institute of Gene Biology of the Russian Academy of Sciences. 


  • Princeton University, Scripps Research Institute (USA), 

  • University of Naples Federico II, IRET – Institute of Research on Terrestrial Ecosystems, CNR (Italy), 

  • FAME Laboratory, Center for Research and Technology Thessaly (Greece), 

  • Laboratory of Immunopathology, Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk (Poland), 

  • Research Center of Genetics and Life Sciences of the «Sirius» University of Science and Technology, 

  • Laboratory of Intercellular Signaling in the Norm and in Pathology of the V. A. Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 

  • Laboratory of Animal Biochemical Genetics of the Institute of Molecular Genetics of the National Research Center «Kurchatov Institute», 

  • Laboratory of Neurogenetics of the I. P. Pavlov Institute of  Physiology of the Russian Academy of Sciences, 

  • Department of Biology and General Genetics of the Faculty of General Medicine of the I. M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University), 

  • Research and Education Center «Photonics and IR engineering» of the Bauman Moscow State Technical University (Russia): joint research and publications. 

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maksimenko o., bartkuhn m., stakhov v., herold m., zolotarev n., jox t., buxa m.k., kirsch r., bonchuk a., fedotova a., kyrchanova o., renkawitz r., georgiev p.
Two New Insulator Proteins, Pita and ZIPIC, Target CP190 to Chromatin. Genome Research 25(1): 89–99 (2015).
kyrchanova o, maksimenko o, ibragimov a, sokolov v, postika n, lukyanova m, schedl p, georgiev p.
The insulator functions of the Drosophila polydactyl C2H2 zinc finger protein CTCF: Necessity versus sufficiency. Sci Adv. (2020) 6(13):eaaz3152.
erokhin m., elizar'ev p., parshikov a., schedl p., georgiev p., chetverina d.
Transcriptional Read-Through is not Sufficient to Induce an Epigenetic Switch in the Silencing Activity of Polycomb Response Elements. Proceedings of the National Academy of Sciences 112(48): 14930–14935 (2015).
gilmutdinov r, kozlov en, yakovlev kv, olenina lv, kotov aa, barr j, zhukova m, schedl p, shidlovskii yv.
The 3'UTR of the Drosophila CPEB translation factor gene orb2 plays a crucial role in spermatogenesis. Development. (2021) 148(17):dev198788.
kyrchanova o., mogila v., wolle d., deshpande g., parshikov a., cléard f., karch f., schedl p., georgiev p.
Functional Dissection of the Blocking and Bypass Activities of the Fab-8 Boundary in the Drosophila Bithorax Complex. PLoS Genetics 12(7): e1006188 (2016).
m. fujioka, h. mistry, p. schedl, j. jaynes
Determinants of Chromosome Architecture: Insulator Pairing in cis and in trans. PLoS Genet (2016) 24;12(2):e1005889.
postika n, metzler m, affolter m, müller m, schedl p, georgiev p, kyrchanova o.
Boundaries mediate long-distance interactions between enhancers and promoters in the Drosophila Bithorax complex. PLoS Genet. (2018) 14(12):e1007702.
kyrchanova o, kurbidaeva a, sabirov m, postika n, wolle d, aoki t, maksimenko o, mogila v, schedl p, georgiev p.
The bithorax complex iab-7 Polycomb response element has a novel role in the functioning of the Fab-7 chromatin boundary. PLoS Genet. (2018) 14(8):e1007442.
barr j., charania s., gilmutdinov r., yakovlev k., shidlovskii y., schedl p.
The CPEB translational regulator, Orb, functions together with Par proteins to polarize the Drosophila oocyte. PLoS Genetics(2019) 15(3):e1008012
kyrchanova o, sabirov m, mogila v, kurbidaeva a, postika n, maksimenko o, schedl p, georgiev p.
Complete reconstitution of bypass and blocking functions in a minimal artificial Fab-7 insulator from Drosophila bithorax complex. Proc Natl Acad Sci USA. (2019); 116(27):13462-13467.
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