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Laboratory for ultra-fast calorimetry

Contract number
14.Y26.31.0019
Time span of the project
2017-2021

As of 15.02.2021

32
Number of staff members
83
scientific publications
General information
Name of the project: Developing methods for ultra-fast calorimeetry for research of polymers, composite materials and biomaterials

Strategy for Scientific and Technological Development Priority Level: б

Goals and objectives
Research directions: Ultra-fast calorimetry, thermophyscial properties of matters and materials

Project objective: Developing methods for ultra-fast calorimetry for research of thermophysical and therrmochemical properties of prospective substances and materials with low thermodynamical and kinetic stability: polymers and polymer components, oligo- and polypeptides, proteins, macrocyclic receptors, medical substances, ion liquids etc.

The practical value of the study
Based on the fast scanning calorimetry method, new approaches were developed allowing studying melting of a wide range of materials (polyfunctional organic compounds, including drugs and biomolecules, polymers and biopolymers); reactivity and kinetics of solid-state reactions of oligopeptides; conditions for the formation and the stability of the amorphous forms of drugs; kinetics of nucleation and crystallization of fast crystallizing polymers. New methods for determining the phase transition thermodynamics of organic non-electrolytes were developed, allowing determination of the fusion enthalpies and vapor pressures of low-volatile compounds, heat capacities of the supercooled liquids, adjustment of fusion enthalpy to the standard temperature.

Education and career development:

A new lecture course “Theory and practice of fast scanning calorimetry” was developed and is now taught to the magisters of the A.M.Butlerov Chemical Institute.

2 PhD and 2 Doc.sci. theses were successfully defended.

Other results:

We have conducted the «International Seminar on Advanced Calorimetry (ISAC) in 2017, 2018, 2019.

Collaborations:

Joint research and publications with the Martin Luther University Halle-Wittenberg (Germany), University of Latvia, Riga (Latvia), Kazan National Research Kazan National Research Technological University (Russia), Institute of Organic and Physical Chemistry and Kazan Physical-Technical Institute of Kazan scientific center of Russian Academy of Sciences (Russia).

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Abdelaziz, A., Zaitsau, D.H., Mukhametzyanov, T.A., Solomonov, B.N., Cebe, P., Verevkin, S.P., Schick, C.
Melting temperature and heat of fusion of cytosine revealed from fast scanning calorimetry, Thermochimica Acta, 2017, 11 (657)
Yagofarov, M.I., Lapuk, S.E., Mukhametzyanov, T.A., Ziganshin, M.A., Schick, C., Solomonov, B.N.
Thermochemical properties of 1,2,3,4-tetraphenylnaphthalene and 1,3,5-triphenylbenzene in crystalline and liquid states studied by solution and fast scanning calorimetry, Journal of Molecular Liquids, 2019, 03 (278)
Yagofarov, M.I., Lapuk, S.E., Mukhametzyanov, T.A., Ziganshin, M.A., Valiakhmetov, T.F., Solomonov, B.N.
The fusion thermochemistry of self-associated aromatic compounds at 298.15 K studied by solution calorimetry, Journal of Chemical Thermodynamics, 2019, 10 (137)
Sedov, I., Magsumov, T., Abdullin, A., Yarko, E., Mukhametzyanov, T., Klimovitsky, A., Schick, C.
Influence of the cross-link density on the rate of crystallization of poly(ε-caprolactone), Polymers, 2018, 08 (10)
Andrianov, R.A., Androsch, R., Zhang, R., Mukhametzyanov, T.A., Abyzov, A.S., Schmelzer, J.W.P., Schick, C.
Growth and dissolution of crystal nuclei in poly(l-lactic acid) (PLLA) in Tammann's development method, Polymer, 2020, 05 (196)
Lapuk, S.E., Zubaidullina, L.S., Ziganshin, M.A., Mukhametzyanov, T.A., Schick, C., Gerasimov, A.V.
Kinetic stability of amorphous solid dispersions with high content of the drug: A fast scanning calorimetry investigation, International Journal of Pharmaceutics, 2019, 05 (562)
Safiullina, A.S., Buzyurov, A.V., Ziganshina, S.A., Gerasimov, A.V., Schick, C., Gorbatchuk, V.V., Ziganshin, M.A.
Using fast scanning calorimetry to study solid-state cyclization of dipeptide L-leucyl-L-leucine, Thermochimica Acta, 2020, 10 (692)
Mukhametzyanov, T.A., Sedov, I.A., Solomonov, B.N., Schick, C.
Fast scanning calorimetry of lysozyme unfolding at scanning rates from 5 K/min to 500,000 K/min, Biochimica et Biophysica Acta - General Subjects, 2018, 09 (1862)
Nagrimanov, R.N., Samatov, A.A., Nasyrova, T.M., Buzyurov, A.V., Mukhametzyanov, T.A., Schick, C., Solomonov, B.N., Verevkin, S.P.
Long-chain linear alcohols: Reconciliation of phase transition enthalpies, Journal of Chemical Thermodynamics, 2020, 07 (146)
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