Spin Hyperpolarisation Laboratory

Scientific results:

The aim of the project was to develop nuclear spin hyperpolarization methods based on the use of multiple switching of the magnetic field to optimize the processes of creation, long-term preservation, and transfer of nonequilibrium spin polarization, which turned out to be especially in demand for amplifying weak NMR signals of heteronuclei with low gyromagnetic ratio values. The project proposed and applied experimental methods for targeted manipulation of spin hyperpolarization, namely, by transferring polarization to selected groups of spins and effectively preserving the spin order. To create nuclear spin hyperpolarization, the project used three approaches: 1) nuclear polarization in photo-induced processes in solutions - chemically induced dynamic polarization of nuclei (photo-CIDNP); 2) photo-DNP experiments in solids; 3) the method based on the parahydrogen-induced polarization of nuclei (PHIP), was used in two versions, namely PHIP with catalytic hydrogenation by parahydrogen and the SABRE version - this is PHIP without hydrogenation, a method based on the transfer of the singlet order of parahydrogen to the spins of the substrate nuclei in the reaction of reversible binding with an organometallic catalyst of both the parahydrogen molecule and the polarizable substrate (SABRE from the English signal amplification by reversible exchange), The project consistently uses a strategy based on the use of multiple switching of the magnetic field to select optimal conditions not only for the formation of polarization, but also its transfer, storage and detection. This approach with several fields made it possible to develop reliable and effective methods for signal amplification in NMR due to spin hyperpolarization, which were applied in current studies of physicochemical processes.

Education and personnel occupational retraining:

Over three years, 2 doctoral and 7 candidate dissertations have been defended,

11 accepted to postgraduate studies 

Cooperation:

• University of Leipzig, Germany
• University of Würzburg, Germany
• Technical University of Darmstadt, Germany
• University of Paris France
• University Southampton, UK