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The project is aimed at the development of methods of spin hyperpolarisation for a significant increase of the sensitivity of nuclear magnetic resonance (NMR).

In this project, the laboratory will develop new approaches to the purposeful manipulation of the non-equilibrium spin hyperpolarisation, including methods of polarisation transfer to target spin groups and efficient spin order storage. For this purpose, we will use several magnetic fields, which will allow to achieve the optimal conditions for the formation, transfer, storage, and detection of hyperpolarisation. The multi-field approach will allow to implement stable NMR signal amplification schemes, which is vitally important for a number of applications. In particular, the developed methods will be used to solve relevant problems, including fast and effective screening of medications in pharmaceutical applications.

Name of the project: Nuclear spin hyperpolarisation in repeatedly switched fields

Strategy for Scientific and Technological Development Priority Level: в

Goals and objectives

To achieve the objective, significant increasing NMR sensitivity, our researchers will solve the following goals and develop corresponding research directions:

  • The use of repeatedly switched magnetic fields in experiments involving dynamic nuclear polarisation (DNP) with dissolution for efficient spin hyperpolarisation storage;
  • The development of multi-field methods of photo-DNP with fast dissolution of the sample;
  • The development of new methods of NMR signal amplification in zero and ultra-low magnetic fields (ZULF-NMR).

The development of applications of spin hyperpolarisation in repeatedly switched magnetic fields for fast and effective screening of pharmaceuticals.

The practical value of the study
Projected research results: 

  1. In consequence of the use of multi-field approaches, dissolution DNP will become a more stable and     widespread    method;
  2. We will develop, optimise, and use new methods based on nuclear hyperpolarisation in liquids;
  3. ZULF-NMR methods will become more sensitive, diverse, and universal;
  4. New approaches to fast and effective screening of medications will become available.
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